Regulation of protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein K63-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DEF6, DOK2, and LIMD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein K63-linked ubiquitination activity versus DEF6 in CCRCC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DEF6 →	+0.393	+0.047	<.001	<.001	3	6
LSCC	DOK2 →	+0.578	+0.072	<.001	<.001	3	6
LSCC	LIMD2 →	+0.514	+0.068	<.001	<.001	3	6
LSCC	XAF1 →	+0.564	+0.039	<.001	<.001	3	6
HNSC	OGFR →	+0.293	+0.049	<.001	.003	3	6
HNSC	ARHGAP15 →	+0.527	+0.056	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900044 vs DEF6 — CCRCC

Explore this scatter interactively →