Regulation of protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein K63-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BZW1P2, SPCS2P4, and ZNF497, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein K63-linked ubiquitination activity versus BZW1P2 in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BZW1P2 →	+0.791	+0.659	.003	<.001	3	5
OV	SPCS2P4 →	+1.046	+0.670	<.001	<.001	3	5
BRCA	ZNF497 →	-0.391	-0.541	.002	<.001	3	5
UCEC	TRIM45 →	-0.506	-0.499	<.001	.002	3	5
UCEC	ZNF3 →	-0.527	-0.436	.002	.007	3	4
OV	FKBP1C →	+1.184	+0.710	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900044 vs BZW1P2 — OV

Explore this scatter interactively →