Regulation of protein K63-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein K63-linked ubiquitination pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2N, MAPK1, and ABL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2N grouped by Regulation of protein K63-linked ubiquitination-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	UBE2N →	-0.304	-1.025	<.001	.008	2	5
BREAST	MAPK1 →	+0.109	+0.344	.002	.007	3	4
BREAST	ABL1 →	-0.112	-0.442	<.001	.004	3	4
URINARY_TRACT	UBE2L3 →	-0.163	-0.333	.005	.003	1	5
CNS	PTPN22 →	-0.381	-0.580	<.001	.004	2	4
BLOOD_Leukemia	GPS2 →	-0.308	-0.472	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2N by Regulation of protein K63-linked ubiquitination activity — LIVER

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