Regulation of protein K63-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein K63-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E4F1, PLCB2, and DGKG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, E4F1 grouped by Regulation of protein K63-linked ubiquitination-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	E4F1 →	+0.671	+1.520	.003	.003	3	4
CNS	PLCB2 →	+0.891	+0.712	<.001	.003	3	3
CNS	DGKG →	-1.295	-0.657	.009	.006	3	3
LUNG_NSCLC_LUSC	FSIP2 →	+1.276	+0.357	.008	<.001	2	4
BREAST	NNAT →	+0.822	+0.719	.001	.001	3	3
SOFT_TISSUE	HIBADH →	-0.716	-0.499	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

E4F1 by Regulation of protein K63-linked ubiquitination activity — LIVER

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