Regulation of protein K63-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein K63-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF126, HNRNPA1, and CDC25A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein K63-linked ubiquitination activity versus RNF126 in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNF126 →	+0.808	+0.397	.003	<.001	3	6
BREAST	HNRNPA1 →	+0.493	+0.239	.006	.004	3	5
BREAST	CDC25A →	+0.688	+0.197	.003	.008	3	5
STOMACH	PRDX2 →	+1.841	+0.563	.002	.001	3	5
STOMACH	CSNK1G2 →	+0.909	+0.409	.001	<.001	3	5
BLOOD_Myeloma	DCK →	+1.386	+0.250	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900044 vs RNF126 — STOMACH

Explore this scatter interactively →