Negative regulation of cellular response to hypoxia

Across TCGA patient cohorts, RNA activity of the Negative regulation of cellular response to hypoxia pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S89, DDX18, and DNAJC7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to hypoxia activity versus DDX21_S89 in LUAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DDX21_S89 →	-0.650	-0.040	<.001	<.001	3	8
BRCA	DDX18 →	-0.323	-0.036	.003	<.001	3	7
LSCC	DNAJC7 →	-0.272	-0.046	<.001	<.001	3	7
BRCA	EIF3H_S183 →	-0.590	-0.036	.004	.004	3	7
LUAD	NIFK_T223 →	-0.774	-0.039	<.001	.001	3	7
GBM	LYAR →	-0.329	-0.053	.003	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900038 vs DDX21_S89 — LUAD

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