Negative regulation of cellular response to hypoxia

Across TCGA patient cohorts, RNA activity of the Negative regulation of cellular response to hypoxia pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGLN3, MIR210HG, and NOL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to hypoxia activity versus EGLN3 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EGLN3 →	+1.494	+0.126	.002	.002	2	6
BRCA	MIR210HG →	+0.846	+0.215	<.001	<.001	3	5
CCRCC	NOL3 →	+0.724	+0.349	.001	.002	3	5
LUAD	PFKP →	+0.558	+0.175	.005	<.001	3	5
LUAD	EPN3 →	+0.560	+0.185	.006	.002	3	4
BRCA	ADM →	+1.351	+0.269	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900038 vs EGLN3 — OV

Explore this scatter interactively →