Regulation of cellular response to heat

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to heat pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STT3B, RPL27, and HNRNPLL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to heat activity versus STT3B in PDAC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	STT3B →	-0.351	-0.032	.004	.001	3	6
BRCA	RPL27 →	-0.225	-0.035	<.001	<.001	3	5
HNSC	HNRNPLL →	+0.194	+0.064	.001	.009	2	6
BRCA	RPL5 →	-0.177	-0.036	<.001	<.001	3	5
GBM	ELOVL1 →	-0.358	-0.043	.002	.004	3	5
LUAD	RAB3D →	-0.294	-0.037	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900034 vs STT3B — PDAC

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