Regulation of substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Regulation of substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA3, DUSP14, and TMEM150A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of substrate adhesion-dependent cell spreading activity versus ANXA3 in OVARY (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ANXA3 →	+3.319	+0.166	.002	.003	3	5
CNS	DUSP14 →	+0.662	+0.179	.007	.002	3	5
OESOPHAGUS	TMEM150A →	-1.285	-0.250	<.001	<.001	3	5
BREAST	CAV2 →	+2.850	+0.177	.007	.009	3	5
LUNG_SCLC	TSC22D2 →	+0.650	+0.190	.004	.005	3	4
LUNG_NSCLC_LUAD	C6orf15 →	+1.044	+0.173	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900024 vs ANXA3 — OVARY

Explore this scatter interactively →