Regulation of protein kinase C activity

Across TCGA patient cohorts, RNA activity of the Regulation of protein kinase C activity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, KLF8, and PCDHB9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein kinase C activity activity versus EGFR in GBM (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EGFR →	+2.748	+0.868	<.001	<.001	3	6
LUAD	KLF8 →	+0.740	+0.766	<.001	<.001	3	4
CCRCC	PCDHB9 →	+0.811	+0.675	<.001	<.001	3	4
BRCA	PLS3 →	+1.399	+0.706	<.001	<.001	3	4
OV	B3GLCT →	+0.538	+0.791	.002	.002	3	4
OV	C10orf143 →	-0.270	-0.565	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900019 vs EGFR — GBM

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