Q-omics provides the consensus-scored C10orf143 profile across patient tissues and cancer cell-line models. C10orf143 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, C10orf143 is differentially expressed in 14, with the highest sampling consensus in THCA. Additionally, C10orf143 RNA expression shows 18,362 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, THCA, and UVM as cancer lineages where C10orf143 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C10orf143 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C10orf143 survival associations across molecular data types. C10orf143 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C10orf143 RNA expression–survival associations across cancer types. High C10orf143 expression shows unfavorable associations in UVM, but favorable associations in KIRP, LUAD, HNSC, LGG and PAAD. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for C10orf143 RNA expression.
This table summarizes C10orf143 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for C10orf143. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C10orf143 shows lower tumor expression in THCA, KIRC, BLCA, COAD, KICH and LUAD. The THCA box plot shows higher C10orf143 RNA expression in normal versus tumor tissue (log2 FC = −0.918, t-test p < 0.001).
This table shows molecular features associated with C10orf143 in patient tissues and cancer cell lines. In patient samples, C10orf143 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, C10orf143 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia.
