Negative regulation of cytokine production involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytokine production involved in inflammatory response pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP1, HNRNPD, and CSTF3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP1 grouped by Negative regulation of cytokine production involved in inflammatory response-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IGFBP1 →	-0.261	-1.202	.004	.002	3	3
SKIN	HNRNPD →	-0.193	-1.702	<.001	<.001	3	3
SKIN	CSTF3 →	+0.264	+1.644	<.001	<.001	3	3
BLOOD_Lymphoma	EP400 →	+0.458	+1.563	.008	<.001	2	4
BREAST	AHCTF1 →	+0.493	+0.916	.003	.009	3	3
LIVER	PKM →	-0.633	-2.271	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP1 by Negative regulation of cytokine production involved in inflammatory response activity — BLOOD_Leukemia

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