Cell junction disassembly

Across TCGA patient cohorts, RNA activity of the Cell junction disassembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1B, TLR4, and CNRIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell junction disassembly activity versus PDE1B in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDE1B →	+0.632	+0.161	<.001	<.001	3	6
GBM	TLR4 →	+0.766	+0.113	<.001	.001	3	6
OV	CNRIP1 →	+0.738	+0.163	<.001	<.001	3	6
OV	TM6SF1 →	+0.565	+0.131	<.001	<.001	3	6
OV	FLI1 →	+0.590	+0.155	<.001	<.001	3	6
OV	PIEZO2 →	+0.711	+0.156	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150146 vs PDE1B — OV

Explore this scatter interactively →