Negative regulation of cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1C, MAP7, and RREB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-substrate junction organization activity versus CORO1C in LUNG_NSCLC_LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CORO1C →	+1.040	+0.877	.001	.001	3	6
LUNG_NSCLC_LUAD	MAP7 →	-1.660	-0.829	.008	.004	3	5
LARGE_INTESTINE	RREB1 →	-0.749	-1.006	.003	.003	3	5
LUNG_NSCLC_LUAD	SPOCD1 →	+1.347	+0.648	.009	.005	3	5
SOFT_TISSUE	LLGL2 →	-1.874	-0.313	.007	.005	3	5
BLOOD_Myeloma	IGFBP6 →	+1.580	+0.446	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150118 vs CORO1C — LUNG_NSCLC_LUAD

Explore this scatter interactively →