Positive regulation of cell-substrate junction organization

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell-substrate junction organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPM1F, TLN2, and BGN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-substrate junction organization activity versus PPM1F in UCEC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPM1F →	+0.311	+0.070	<.001	<.001	3	10
BRCA	TLN2 →	+0.770	+0.072	<.001	<.001	3	9
BRCA	BGN →	+0.788	+0.050	<.001	<.001	3	9
PDAC	YME1L1 →	-0.394	-0.067	<.001	<.001	3	9
PDAC	CNN3 →	+0.577	+0.047	<.001	.002	3	9
BRCA	CNRIP1 →	+0.836	+0.072	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150117 vs PPM1F — UCEC

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