Positive regulation of cell-substrate junction organization

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAG1, RGCC, and LDB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-substrate junction organization activity versus IRAG1 in CCRCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IRAG1 →	+0.830	+0.432	.002	.003	2	8
CCRCC	RGCC →	+0.782	+0.437	<.001	<.001	3	6
CCRCC	LDB2 →	+0.957	+0.354	<.001	.006	3	6
CCRCC	RCAN2 →	+0.956	+0.450	.001	.002	3	6
COAD	OLFML1 →	+0.592	+0.146	.001	.009	3	6
COAD	LHFPL6 →	+0.753	+0.181	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150117 vs IRAG1 — CCRCC

Explore this scatter interactively →