Positive regulation of cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-substrate junction organization pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC3, ABR, and TSC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAPPC3 grouped by Positive regulation of cell-substrate junction organization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TRAPPC3 →	-0.308	-0.122	<.001	<.001	3	6
URINARY_TRACT	ABR →	-0.203	-0.132	.008	.001	3	5
BLOOD_Leukemia	TSC2 →	-0.230	-0.075	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ZAN →	+0.234	+0.095	.009	.003	3	5
SKIN	TFRC →	-0.579	-0.098	.002	.001	3	5
CNS	EIF4G1 →	-0.279	-0.114	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAPPC3 by Positive regulation of cell-substrate junction organization activity — OVARY

Explore this box plot interactively →