Regulation of cell-substrate junction organization

Across TCGA patient cohorts, RNA activity of the Regulation of cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01960, SYNDIG1, and MEIS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-substrate junction organization activity versus LINC01960 in COAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC01960 →	+0.121	+0.633	<.001	.002	3	4
BRCA	SYNDIG1 →	+1.095	+0.391	<.001	<.001	3	3
BRCA	MEIS3 →	+1.108	+0.274	<.001	.004	3	3
BRCA	ECM2 →	+1.306	+0.393	<.001	<.001	3	3
OV	SFXN3 →	+0.501	+0.383	.003	.002	3	3
COAD	SEPTIN4 →	+0.507	+1.087	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150116 vs LINC01960 — COAD

Explore this scatter interactively →