Regulation of cell-substrate junction organization

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cell-substrate junction organization pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 68 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Regulation of cell-substrate junction organization pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and HNSC, show the opposite pattern, with higher activity associated with better survival.

MESO, ACC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.261	0.596	<.001	91	view →
ACC	DFS	Tertile	All	0.201	0.575	<.001	87	view →
UVM	DFS	Median	III,IV	0.340	0.708	.002	67	view →
LGG	DFS	Median	All	0.651	0.816	<.001	46	view →
LUAD	DFS	Median	II,III,IV	0.664	0.321	<.001	44	view →
HNSC	DFS	Median	IV	0.772	0.589	.002	34	view →
LUSC	OS	Quartile	II,III,IV	0.280	0.555	.002	34	view →
COAD	DFS	Tertile	IV	0.309	0.658	.005	25	view →
KIRP	DFS	Tertile	All	0.780	0.913	.006	21	view →
THCA	DFS	Tertile	All	0.965	0.711	.002	21	view →
SCLC	DFS	Quartile	III,IV	0.684	0.195	.005	20	view →
GBM	DFS	Tertile	All	0.503	0.261	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0150116–MESO (OS)

Open the MESO breakdown →