Regulation of cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFNA5, TOX, and RIC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EFNA5 grouped by Regulation of cell-substrate junction organization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EFNA5 →	+1.527	+0.703	.001	.006	3	4
BREAST	TOX →	+0.882	+0.716	.003	.003	3	4
LARGE_INTESTINE	RIC1 →	+0.910	+0.824	<.001	.002	3	3
LARGE_INTESTINE	KIAA1191 →	+0.584	+0.922	<.001	.001	3	3
LARGE_INTESTINE	ZYG11B →	+0.431	+0.668	.008	.002	3	3
LARGE_INTESTINE	SNX2 →	+0.685	+0.894	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EFNA5 by Regulation of cell-substrate junction organization activity — STOMACH

Explore this box plot interactively →