Regulation of cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate junction organization pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS18B, HMGB1, and CD99, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS18B grouped by Regulation of cell-substrate junction organization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRPS18B →	-0.164	-0.088	.006	.004	3	6
SKIN	HMGB1 →	-0.275	-0.070	<.001	.005	3	5
SKIN	CD99 →	-0.110	-0.044	.006	.009	3	5
CNS	TRAPPC3 →	-0.379	-0.116	<.001	<.001	3	5
BONE	PPP1R12A →	+0.345	+0.166	.004	.008	2	6
UPPER_AERODIGESTIVE_TRACT	PROCR →	-0.164	-0.089	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS18B by Regulation of cell-substrate junction organization activity — UPPER_AERODIGESTIVE_TRACT

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