Regulation of cell-substrate junction organization

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate junction organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCL, SULT1A2, and MRPS36, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-substrate junction organization activity versus VCL in BLOOD_Leukemia (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VCL →	+1.532	+0.180	.001	.001	3	5
LUNG_NSCLC_LUAD	SULT1A2 →	-1.491	-0.171	.002	.005	3	5
SOFT_TISSUE	MRPS36 →	+0.734	+0.366	.002	.008	3	5
BREAST	SLC39A13 →	+0.863	+0.196	.001	.002	3	5
LARGE_INTESTINE	FAM162A →	-0.992	-0.192	.004	.008	3	5
LIVER	KCNN4 →	+4.568	+0.202	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150116 vs VCL — BLOOD_Leukemia

Explore this scatter interactively →