Protein localization to cell-cell junction

Across TCGA patient cohorts, RNA activity of the Protein localization to cell-cell junction pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGLN, MSRB3, and HEPH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell-cell junction activity versus TAGLN in CCRCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TAGLN →	+1.001	+0.765	<.001	<.001	3	6
CCRCC	MSRB3 →	+0.950	+1.008	<.001	<.001	3	6
GBM	HEPH →	+0.948	+0.649	.001	.007	3	6
CCRCC	CNN1 →	+0.920	+0.582	<.001	<.001	3	5
CCRCC	LMOD1 →	+0.898	+0.637	<.001	<.001	3	5
OV	LINC00702 →	+0.591	+0.898	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150105 vs TAGLN — CCRCC

Explore this scatter interactively →