Neuron-glial cell signaling

Across TCGA patient cohorts, RNA activity of the Neuron-glial cell signaling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMOC2, ACOX3, and CRYBG3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron-glial cell signaling activity versus SMOC2 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMOC2 →	+0.659	+0.656	.003	<.001	3	3
LSCC	ACOX3 →	-0.414	-0.374	<.001	.006	3	3
OV	CRYBG3 →	-0.338	-0.129	<.001	<.001	3	3
OV	MAP1B_S1016 →	+1.489	+0.103	<.001	<.001	3	3
OV	PRR14 →	+0.285	+0.130	<.001	.003	3	3
LSCC	CAMSAP2 →	+0.177	+0.336	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150099 vs SMOC2 — UCEC

Explore this scatter interactively →