Neuron-glial cell signaling

Across TCGA pan-cancer cohorts, RNA activity of the Neuron-glial cell signaling pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LIHC and LUAD, show the opposite pattern, with lower activity in tumor tissue.

THCA, KIRP, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	IV	+0.203	<.001	11	view →
KIRP	All	II,III,IV	+0.107	<.001	11	view →
LIHC	Male	II,III,IV	−0.214	<.001	8	view →
HNSC	Male	II,III,IV	+0.064	.006	7	view →
KIRC	Male	II,III,IV	+0.057	<.001	6	view →
LUAD	All	All	−0.090	.005	5	view →
KICH	Female	II,III,IV	−0.118	<.001	4	view →
COAD	Male	III,IV	−0.077	.005	3	view →
LUSC	All	All	−0.042	.022	3	view →
UCEC	All	All	−0.167	.030	2	view →
PRAD	All	All	−0.062	<.001	2	view →
STAD	All	All	−0.275	.023	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0150099–THCA

Open the THCA breakdown →