Neuron-glial cell signaling

Across TCGA patient cohorts, RNA activity of the Neuron-glial cell signaling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPD3, PRODH, and GRK3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron-glial cell signaling activity versus SNRPD3 in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD3 →	+0.358	+0.496	<.001	.006	3	1
GBM	PRODH →	+0.814	+0.782	.001	<.001	3	1
GBM	GRK3 →	+0.390	+0.526	<.001	.003	3	1
GBM	SEZ6L →	+1.667	+0.608	<.001	<.001	3	1
GBM	SOX10 →	+1.326	+0.636	<.001	.002	3	1
GBM	SLC16A8 →	+0.372	+0.588	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150099 vs SNRPD3 — GBM

Explore this scatter interactively →