Negative regulation of neuroinflammatory response

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuroinflammatory response pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BHMT2, GCDH, and WNT4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BHMT2 grouped by Negative regulation of neuroinflammatory response-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BHMT2 →	-0.317	-1.576	.007	.008	3	4
LARGE_INTESTINE	GCDH →	-0.206	-1.391	.005	<.001	3	3
LARGE_INTESTINE	WNT4 →	-0.168	-1.524	<.001	.002	3	3
SKIN	SLC22A12 →	-0.208	-1.890	.001	.002	3	3
OVARY	STAT5A →	-0.196	-1.558	.005	.001	3	3
OVARY	USP18 →	+0.144	+1.558	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BHMT2 by Negative regulation of neuroinflammatory response activity — LUNG_SCLC

Explore this box plot interactively →