Regulation of protein localization to lysosome

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM24, ZNF639, and FAHD2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM24 grouped by Regulation of protein localization to lysosome-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RBM24 →	-2.293	-2.005	.007	.001	3	3
LIVER	ZNF639 →	+1.020	+2.005	.002	.001	3	3
OESOPHAGUS	FAHD2B →	-1.740	-1.695	.008	.005	3	3
BLOOD_Lymphoma	ELL3 →	+7.865	+1.596	.001	.004	3	3
BLOOD_Lymphoma	POGLUT2 →	-2.909	-1.647	.001	.001	3	3
BLOOD_Lymphoma	KSR1 →	-2.530	-1.649	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM24 by Regulation of protein localization to lysosome activity — LIVER

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