Regulation of protein localization to lysosome

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of protein localization to lysosome pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Regulation of protein localization to lysosome pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and ESCA, show the opposite pattern, with higher activity associated with better survival.

ACC, LUAD, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.401	0.780	<.001	79	view →
LUAD	DFS	Quartile	All	0.736	0.864	.003	67	view →
UCEC	DFS	Median	All	0.785	0.879	.001	60	view →
PAAD	DFS	Quartile	All	0.362	0.645	<.001	58	view →
CESC	DFS	Tertile	III,IV	0.195	0.715	.001	38	view →
UCS	DFS	Median	II,III,IV	0.558	0.189	.002	30	view →
BRCA	OS	Quartile	II,III,IV	0.940	0.989	<.001	22	view →
LUSC	DFS	Median	All	0.284	0.463	.007	21	view →
ESCA	DFS	Quartile	II,III,IV	0.789	0.116	.006	18	view →
KIRC	DFS	Median	III,IV	0.356	0.527	.013	13	view →
DLBC	OS	Tertile	All	0.395	1.000	.005	12	view →
READ	DFS	Tertile	All	0.413	0.732	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0150031–ACC (DFS)

Open the ACC breakdown →