Regulation of protein localization to lysosome

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF9, REST, and LAMTOR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to lysosome activity versus IRF9 in BLOOD_Leukemia (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IRF9 →	+1.513	+1.342	.001	<.001	3	4
PANCREAS	REST →	-0.913	-0.233	.007	.002	3	4
LUNG_SCLC	LAMTOR1 →	+0.927	+1.018	<.001	.001	3	4
BLOOD_Leukemia	HELLS →	-0.974	-0.999	.003	<.001	3	3
BLOOD_Leukemia	CKS2 →	-0.865	-0.879	.005	.002	3	3
BLOOD_Leukemia	SKP2 →	-1.304	-1.055	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0150031 vs IRF9 — BLOOD_Leukemia

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