Positive regulation of inflammasome-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPP4, TGFBR3L, and C5orf58, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammasome-mediated signaling pathway activity versus DPP4 in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DPP4 →	+1.099	+0.212	.005	.002	3	4
GBM	TGFBR3L →	-0.380	-0.208	.001	.003	3	4
UCEC	C5orf58 →	+0.380	+0.175	.004	.001	3	4
GBM	FBXL16 →	-0.706	-0.195	.008	.002	3	3
UCEC	SNORA54 →	-1.260	-0.223	.001	.009	3	3
BRCA	ARAP2 →	+0.571	+0.138	.006	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141087 vs DPP4 — LUAD

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