Negative regulation of inflammasome-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL_S246, CTSS, and NADK_S46, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammasome-mediated signaling pathway activity versus EVL_S246 in BRCA (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EVL_S246 →	+0.591	+0.040	.003	.001	3	6
GBM	CTSS →	+0.705	+0.070	<.001	<.001	3	6
LSCC	NADK_S46 →	+0.807	+0.061	<.001	<.001	3	6
UCEC	ARHGAP45_S569 →	+0.578	+0.128	<.001	<.001	3	6
UCEC	LGALS9 →	+0.399	+0.099	.002	<.001	3	6
GBM	LSP1_S252 →	+0.417	+0.035	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141086 vs EVL_S246 — BRCA

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