Negative regulation of inflammasome-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of inflammasome-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEFB4A, AFF3, and FCGR3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammasome-mediated signaling pathway activity versus DEFB4A in HNSC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DEFB4A →	+2.225	+0.538	.001	.002	3	5
HNSC	AFF3 →	-0.411	-0.551	.002	.001	3	4
LSCC	FCGR3B →	+1.067	+0.755	.003	<.001	3	4
LSCC	PPM1D →	-0.358	-0.595	.002	<.001	3	4
LSCC	DCAKD →	-0.442	-0.506	<.001	.003	3	4
LSCC	HMGN1P8 →	-0.491	-0.471	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0141086 vs DEFB4A — HNSC

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