Inflammasome-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Inflammasome-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX3X, PPP2CA, and CSNK1A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX3X grouped by Inflammasome-mediated signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DDX3X →	-0.474	-1.695	.001	.004	3	9
BLOOD_Leukemia	PPP2CA →	-0.627	-0.889	.003	.004	3	6
SKIN	CSNK1A1 →	-0.189	-0.439	<.001	.007	3	6
LARGE_INTESTINE	MYB →	-0.269	-0.556	.001	.003	3	5
KIDNEY	DHRS1 →	-0.220	-0.738	<.001	.002	3	4
BREAST	ATP5F1B →	-0.366	-0.513	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX3X by Inflammasome-mediated signaling pathway activity — LIVER

Explore this box plot interactively →