Multicellular organismal-level chemical homeostasis

Across TCGA patient cohorts, RNA activity of the Multicellular organismal-level chemical homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MS4A6A, GLIPR1, and ARHGDIB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level chemical homeostasis activity versus MS4A6A in COAD (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MS4A6A →	+0.519	+0.465	.009	.009	3	5
GBM	GLIPR1 →	+0.821	+0.157	<.001	<.001	3	5
LSCC	ARHGDIB →	+0.557	+0.206	<.001	<.001	3	5
LSCC	HJURP →	-0.773	-0.236	<.001	.001	3	5
LSCC	HLA-DOA →	+0.766	+0.175	<.001	.004	3	5
LUAD	MS4A2 →	+0.487	+0.132	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140962 vs MS4A6A — COAD

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