Endolysosomal toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Endolysosomal toll-like receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF6_S684, SAMHD1, and STAT2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endolysosomal toll-like receptor signaling pathway activity versus ARHGEF6_S684 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGEF6_S684 →	+0.784	+0.059	<.001	<.001	3	10
CCRCC	SAMHD1 →	+0.494	+0.077	<.001	<.001	3	9
GBM	STAT2 →	+0.588	+0.066	<.001	<.001	3	9
LSCC	UBA7 →	+0.397	+0.058	<.001	<.001	3	9
GBM	DDX58 →	+0.719	+0.078	<.001	<.001	3	9
OV	DOCK11 →	+0.415	+0.040	.002	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140894 vs ARHGEF6_S684 — LSCC

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