Endolysosomal toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Endolysosomal toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALOX5, CSF2RA, and HLA-DMB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endolysosomal toll-like receptor signaling pathway activity versus ALOX5 in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALOX5 →	+0.771	+0.371	<.001	.003	3	6
GBM	CSF2RA →	+0.771	+0.257	.002	<.001	3	6
GBM	HLA-DMB →	+0.645	+0.274	.008	<.001	3	6
LSCC	GBP1 →	+0.598	+0.280	<.001	.002	3	5
HNSC	GBP5 →	+1.407	+0.256	.001	.002	3	5
HNSC	CXCL11 →	+1.438	+0.170	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140894 vs ALOX5 — LSCC

Explore this scatter interactively →