Endolysosomal toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Endolysosomal toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNPH, FAM174B, and KDM6B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNPH grouped by Endolysosomal toll-like receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SNPH →	-0.411	-1.230	.007	<.001	3	5
PANCREAS	FAM174B →	-1.793	-1.110	<.001	<.001	3	4
SKIN	KDM6B →	+0.838	+1.059	<.001	.001	3	4
LUNG_NSCLC_LUAD	PAN3 →	+0.341	+0.848	.009	<.001	3	4
URINARY_TRACT	PERM1 →	-1.831	-1.491	<.001	<.001	3	4
OVARY	CLBA1 →	-0.814	-1.082	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNPH by Endolysosomal toll-like receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →