Endolysosomal toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Endolysosomal toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM177, MEX3D, and DDX28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endolysosomal toll-like receptor signaling pathway activity versus TMEM177 in SKIN (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM177 →	-0.774	-0.542	.001	.004	3	4
SKIN	MEX3D →	+0.744	+0.626	.005	.002	3	4
SOFT_TISSUE	DDX28 →	-0.903	-0.588	.005	.007	3	4
BLOOD_Myeloma	CD82 →	+3.280	+0.484	<.001	.005	3	4
BLOOD_Myeloma	DEPP1 →	+3.247	+0.597	<.001	<.001	3	4
BLOOD_Lymphoma	RFTN1 →	+2.267	+1.136	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140894 vs TMEM177 — SKIN

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