Obsolete regulation of ncRNA transcription

pathway activity — cross-omics
GO:0140747Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete regulation of ncRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF20B, HNRNPUL1, and MTBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACKIF20B →+0.472+1.159.003<.00134
BRCAHNRNPUL1 →+0.260+0.439.006<.00133
UCECMTBP →+0.613+2.016<.001<.00133
OVDENND10P1 →-0.477-0.420.001<.00133
PDACHNF4A →-0.579-0.520.004.00633
PDACRFC5 →+0.445+1.107<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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