Radial glia-guided pyramidal neuron migration

Across TCGA patient cohorts, RNA activity of the Radial glia-guided pyramidal neuron migration pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOP1B_S1021, HK1, and MTMR12_S716, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Radial glia-guided pyramidal neuron migration activity versus DOP1B_S1021 in LSCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOP1B_S1021 →	-0.482	-0.060	.003	.006	3	4
LSCC	HK1 →	+0.329	+0.063	.001	.006	3	4
LSCC	MTMR12_S716 →	-0.466	-0.076	<.001	.003	3	4
UCEC	CAMSAP2 →	+0.372	+0.120	<.001	.003	3	4
COAD	PRKCD_S302 →	+0.253	+0.063	.001	.001	3	3
LSCC	RHPN2 →	-0.374	-0.079	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140650 vs DOP1B_S1021 — LSCC

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