Radial glia-guided pyramidal neuron migration

Across TCGA patient cohorts, RNA activity of the Radial glia-guided pyramidal neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDPK1, RPL29P24, and POC1B-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Radial glia-guided pyramidal neuron migration activity versus PDPK1 in OV (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDPK1 →	-0.355	-0.628	.002	<.001	3	3
UCEC	RPL29P24 →	-0.483	-0.598	.003	.009	3	3
GBM	POC1B-AS1 →	-0.404	-0.578	.001	.003	3	3
HNSC	GLIPR1L1 →	-0.572	-0.564	.003	.002	3	3
CCRCC	HNRNPA1P38 →	+0.133	+0.476	.002	.005	2	4
GBM	RHPN2 →	-0.860	-0.577	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140650 vs PDPK1 — OV

Explore this scatter interactively →