Radial glia-guided pyramidal neuron migration

Across TCGA cell cohorts, RNA activity of the Radial glia-guided pyramidal neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEST, ZMIZ1, and CXXC5, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Radial glia-guided pyramidal neuron migration activity versus MEST in SOFT_TISSUE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MEST →	+5.771	+0.462	<.001	<.001	3	16
BLOOD_Lymphoma	ZMIZ1 →	+1.808	+0.672	<.001	<.001	3	15
OVARY	CXXC5 →	+2.426	+0.540	<.001	.005	3	7
BREAST	PLEKHA6 →	+1.475	+0.305	.003	.009	3	6
URINARY_TRACT	EPB41L2 →	-2.426	-0.194	.009	.007	3	6
LUNG_SCLC	EPPK1 →	+0.967	+0.528	.006	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140650 vs MEST — SOFT_TISSUE

Explore this scatter interactively →