Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Across TCGA patient cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN5, TIE1, and BANF1P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway activity versus CLDN5 in CCRCC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLDN5 →	-1.177	-0.198	<.001	<.001	3	4
CCRCC	TIE1 →	-0.578	-0.109	.001	.003	3	4
GBM	BANF1P1 →	+0.659	+0.124	.008	.009	3	3
LUAD	TRIP11 →	+0.312	+0.082	.002	.006	3	3
LUAD	CXXC1 →	-0.268	-0.087	.002	.003	2	4
CCRCC	NOS2 →	-0.643	-0.153	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140627 vs CLDN5 — CCRCC

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