Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Across TCGA pan-cancer cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway pathway is associated with patient survival in 29 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and UCS, show the opposite pattern, with higher activity associated with better survival.

COAD, UVM, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.871	0.744	<.001	46	view →
UVM	DFS	Tertile	All	0.312	0.781	.001	38	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
READ	OS	Quartile	II,III,IV	1.000	0.457	.001	34	view →
LGG	OS	Tertile	All	0.651	0.361	<.001	25	view →
THCA	OS	Tertile	All	0.755	1.000	.013	23	view →
SKCM	OS	Median	All	0.831	0.741	.006	23	view →
ESCA	DFS	Median	IV	0.213	0.626	.026	18	view →
OV	DFS	Quartile	II,III,IV	0.453	0.600	.008	16	view →
SCLC	DFS	Quartile	II,III,IV	0.968	0.274	.024	13	view →
STAD	DFS	Tertile	All	0.469	0.595	.022	13	view →
CHOL	DFS	Quartile	II,III,IV	0.189	0.572	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

GO:0140627–COAD (OS)

Open the COAD breakdown →