Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYRM7, TRAF3IP1, and EDDM13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LYRM7 grouped by Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LYRM7 →	+0.864	+0.358	.002	.002	3	4
LUNG_SCLC	TRAF3IP1 →	-0.917	-0.256	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	EDDM13 →	-0.896	-0.330	.001	<.001	3	4
LUNG_NSCLC_LUAD	TMEM150A →	-0.665	-0.131	.002	.002	3	4
BLOOD_Leukemia	GNAL →	-0.324	-0.148	.001	.003	3	3
BLOOD_Leukemia	COPRS →	-0.828	-0.184	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LYRM7 by Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway activity — LIVER

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