Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A4, RARG, and TUBGCP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A4 grouped by Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC25A4 →	+0.204	+0.123	.006	.009	3	5
UPPER_AERODIGESTIVE_TRACT	RARG →	+0.176	+0.141	.002	<.001	3	4
BONE	TUBGCP2 →	-0.318	-0.080	.007	.006	3	4
BONE	MAP3K3 →	-0.468	-0.090	<.001	.007	3	4
SOFT_TISSUE	MLLT11 →	-0.245	-0.112	.009	.003	3	4
OESOPHAGUS	AGAP3 →	-0.161	-0.144	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A4 by Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway activity — LUNG_SCLC

Explore this box plot interactively →