Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FEM1B, APPBP2, and PJA2, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway activity versus FEM1B in OESOPHAGUS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FEM1B →	+1.138	+0.168	<.001	<.001	3	17
BREAST	APPBP2 →	+1.330	+0.097	<.001	<.001	3	15
BLOOD_Lymphoma	PJA2 →	+1.081	+0.067	<.001	<.001	3	14
OVARY	CUL2 →	+0.794	+0.080	<.001	<.001	2	13
UPPER_AERODIGESTIVE_TRACT	ZNF805 →	+0.611	+0.078	.006	.009	2	13
OESOPHAGUS	WAC →	+1.198	+0.158	.003	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140627 vs FEM1B — OESOPHAGUS

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