Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS6, PDE6D, and CAPZA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway activity versus MRPS6 in PANCREAS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRPS6 →	+1.367	+0.881	.002	.008	3	5
UPPER_AERODIGESTIVE_TRACT	PDE6D →	+0.688	+1.667	.007	<.001	3	5
URINARY_TRACT	CAPZA2 →	+0.787	+2.139	<.001	<.001	3	5
LUNG_NSCLC_LUAD	TINCR →	-2.125	-0.871	.001	.001	3	5
OESOPHAGUS	AIDA →	+1.041	+1.742	<.001	<.001	3	5
BLOOD_Myeloma	GALNT11 →	+2.454	+0.206	<.001	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140627 vs MRPS6 — PANCREAS

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