Granzyme-mediated programmed cell death signaling pathway

Across TCGA patient cohorts, RNA activity of the Granzyme-mediated programmed cell death signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, SEPTIN1, and STAT1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granzyme-mediated programmed cell death signaling pathway activity versus SASH3 in HNSC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SASH3 →	+0.452	+0.135	<.001	<.001	3	9
BRCA	SEPTIN1 →	+0.887	+0.120	<.001	<.001	3	9
BRCA	STAT1 →	+0.818	+0.106	<.001	<.001	3	9
COAD	VAMP5 →	+0.690	+0.095	<.001	<.001	3	9
BRCA	WAS →	+0.463	+0.109	<.001	<.001	3	9
BRCA	CD48 →	+0.942	+0.111	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140507 vs SASH3 — HNSC

Explore this scatter interactively →